I don't have a huge collection of indie games, but I do have a pretty good selection. Something I noticed the other day is that I really hate perfect binding on little books. Dogs in the Vineyard, The Shab-al-Hiri Roach, and The Mountain Witch are all perfect bound and relatively hard for me to read. I guess it' because the pages won't lie flat. Drives me nuts. On the other hand, My Life with Master and In a Wicked Age are much easier for me to get into, just because they're saddle-stitched.
I had the Infected saddle-stitched on a whim. I'm really glad I did. All my published designs will be saddle stitched in the future.